Two papers on African Pygmies published

By | January 21, 2016

PygmyTogetherCongratulations to Benson Hsieh on his two papers that were recently accepted for publication in Genome Research. Both result from our close collaboration with Michael Hammer, Benon’s PhD co-supervisor.

In the first paper, we infer a complex demographic model for Central African Pygmies and neighboring farmers. We then use that model as the basis for whole-genome neutral simulations that account for recombination and mutation rate heterogeneity. Those simulations then act as a null model for scanning the genome for evidence of natural selection.

In the second paper, we use a similar null-model approach to test for evidence of archaic admixture into the ancestors of contemporary pygmies. We show not only that such admixture occurred, but that it likely occurred several times.