How different do we expect the fitness effects of a new mutation to be in different populations? And how does the expected difference depend on the function of the mutated gene, the divergence of the two populations, and other factors?
In our preprint just posted on bioRxiv, we address these questions by introducing the concept of a joint distribution of fitness effects (DFE) between populations and inferring the joint DFE between populations of humans, fruitflies, and wild tomatoes. Plus, code for carrying out this sort of analysis is now available in dadi.
We’re particularly excited about this work, because it offers a new genome-wide perspective on the genetics of population divergence. There is still a great deal to learn about the joint DFE, which will require both more applications to data and more methodological development.
If this sounds interesting, we’re hiring postdocs.