Author Archives: Ryan Gutenkunst

GWAS publications preprint updated

By | March 20, 2018

We’ve posted an updated version of our bioRxiv preprint on the ability of genome-wide association studies to spur subsequent research into newly associated genes. Most importantly, we found that the effect of GWAS has declined dramatically, suggesting that researchers are following-up on GWAS much less than they used to. Although our work does not show why… Read More »

Our research in art

By | September 26, 2017

Our department head, Joyce Schroeder, had the wonderful idea to engage some of UA’s fine arts students to represent our department’s research. I particularly like Elena Makansi‘s representation of our work!

Preprint on filtering genetic variants in cancer

By | September 13, 2017

Our recent work with Erik Knudsen on variant calling in tumors is now on bioRxiv. The paper introduces a new approach for analyzing genetic variants called from next-gen sequencing of tumors. A key challenge in such sequencing is spurious variants calls, particularly when sequencing tumors that have been xenografted into mice. We introduce and characterize a… Read More »

Paper on genetic adaptation in Siberians published

By | September 13, 2017

Our collaborative paper with Michael Hammer on polygenic adaptation in Siberians has been published in MBE. In the paper, we develop a comprehensive model of the join demographic history of Europeans, East Asians, and Siberians. We then use that model as a null model to scan for gene sets enriched in signatures of population-specific adaptation. Three… Read More »