We’ve posted an updated version of our bioRxiv preprint on the ability of genome-wide association studies to spur subsequent research into newly associated genes. Most importantly, we found that the effect of GWAS has declined dramatically, suggesting that researchers are following-up on GWAS much less than they used to. Although our work does not show why… Read More »
Our paper with the Knudsen group on filtering mouse contamination from genome sequences of xenograft tumors is now in press at Bioinformatics. Congratulations to Brian!
Our department head, Joyce Schroeder, had the wonderful idea to engage some of UA’s fine arts students to represent our department’s research. I particularly like Elena Makansi‘s representation of our work!
Our recent work with Erik Knudsen on variant calling in tumors is now on bioRxiv. The paper introduces a new approach for analyzing genetic variants called from next-gen sequencing of tumors. A key challenge in such sequencing is spurious variants calls, particularly when sequencing tumors that have been xenografted into mice. We introduce and characterize a… Read More »
Our collaborative paper with Michael Hammer on polygenic adaptation in Siberians has been published in MBE. In the paper, we develop a comprehensive model of the join demographic history of Europeans, East Asians, and Siberians. We then use that model as a null model to scan for gene sets enriched in signatures of population-specific adaptation. Three… Read More »