Author Archives: Ryan Gutenkunst

Preprint on GWAS effects on biomedical research

By | February 7, 2017

Critics of the large investment made into genome wide association studies have noted that few GWAS results have had direct clinical impact. Supporters note that GWAS can have major indirect impact by revealing novel genes involved in a disease and motivating follow-up research. But this indirect impact has never been measured. In our manuscript, we… Read More »

Paper on triallelic population genomics published

By | March 30, 2016

Congratulations to Aaron Ragsdale on his paper that was just accepted for publication in Genetics. In it, we develop a novel diffusion model for trialleic sites, which required some non-trivial applied mathematics. We then apply the model to mutually nonsynonymous codons in Drosophila, to infer the correlation between selection coefficients for mutations at the same… Read More »