Population genetic inference based on the statistics of single loci, as summarized in the allele frequency spectrum, is known to be powerful for inferring demographic history. But substantial additional information is carried in two-locus statistics, which additionally capture patterns of linkage disequilibrium (LD). In this work, we developed a novel framework for demographic inference from… Read More »
Critics of the large investment made into genome wide association studies have noted that few GWAS results have had direct clinical impact. Supporters note that GWAS can have major indirect impact by revealing novel genes involved in a disease and motivating follow-up research. But this indirect impact has never been measured. In our manuscript, we… Read More »
There’s a nice story about our work with Michael Hammer on Pygmy evolutionary history in our local paper, the Arizona Daily Star.
Congratulations to Aaron Ragsdale on defending his Ph.D. thesis! Aaron will be starting a postdoc in the group of Simon Gravel in March 2017.
Congratulations to Brian Mannakee on his paper that just came out in PLoS Genetics. In it, we use dynamical systems biology models to predict rates of protein domain evolution. The success of these predictions suggests that natural selection is acting to preserve network dynamics in the face of perturbations from mutations. Although the models are… Read More »