Category Archives: Uncategorized

Preprint on demographic history inference

By | February 15, 2017

Population genetic inference based on the statistics of single loci, as summarized in the allele frequency spectrum, is known to be powerful for inferring demographic history. But substantial additional information is carried in two-locus statistics, which additionally capture patterns of linkage disequilibrium (LD). In this work, we developed a novel framework for demographic inference from… Read More »

Preprint on GWAS effects on biomedical research

By | February 7, 2017

Critics of the large investment made into genome wide association studies have noted that few GWAS results have had direct clinical impact. Supporters note that GWAS can have major indirect impact by revealing novel genes involved in a disease and motivating follow-up research. But this indirect impact has never been measured. In our manuscript, we… Read More »