Category Archives: Uncategorized

Science Cafe on Genetic Testing

By | January 10, 2020

Last night Ryan gave a public science talk about genetic testing at the Saddlebrooke retirement community. It was a great experience, and the audience had well-informed questions. Watch the recording here: https://www.youtube.com/watch?v=je5GcyU6CYc.

Welcome Xin!

By | November 20, 2019

We are excited to welcome Xin Huang as a postdoc in the group. As a PhD student, Xin carried out beautiful work characterizing differences in selection between human populations. With the Gutenkunst group, he’ll be pushing our recent joint DFE work forward.

Congratulations Brian!

By | October 25, 2019

Congratulations to Brian Mannakee, who just defended his Ph.D. dissertation “Statistical methods for improving low frequency variant calling in cancer genomics”. Dr. Mannakee is leaving the Gutenkunst group to become a Bioinformatics Scientist at Foundation Medicine.

Cancer mutation calling preprint

By | October 8, 2019

Cells within a tumor are genetically diverse, and low-frequency mutations can have important implications for understanding treatment resistance and tumor evolution. But detecting such mutations is difficult. We developed BATCAVE as an improved algorithm for detecting mutations within tumors by modeling a key aspect of tumor biology. Namely, each individual tumor has its own profileā€¦ Read More »

Joint DFE preprint

By | July 16, 2019

How different do we expect the fitness effects of a new mutation to be in different populations? And how does the expected difference depend on the function of the mutated gene, the divergence of the two populations, and other factors? In our preprint just posted on bioRxiv, we address these questions by introducing the conceptā€¦ Read More »