Our recent work with Erik Knudsen on variant calling in tumors is now on bioRxiv. The paper introduces a new approach for analyzing genetic variants called from next-gen sequencing of tumors. A key challenge in such sequencing is spurious variants calls, particularly when sequencing tumors that have been xenografted into mice. We introduce and characterize a… Read More »
Our collaborative paper with Michael Hammer on polygenic adaptation in Siberians has been published in MBE. In the paper, we develop a comprehensive model of the join demographic history of Europeans, East Asians, and Siberians. We then use that model as a null model to scan for gene sets enriched in signatures of population-specific adaptation. Three… Read More »
Ryan is please to announce that he has been promoted to Associate Professor with tenure. He gives his heartfelt thanks all his current and former students and postdocs. They truly accomplish the groups’ research, and mentoring them is the best part of his job. He also thanks all his colleagues: within MCB, the University of Arizona,… Read More »
Our paper on using two-locus statistics for demographic history inference has been accepted for publication in Genetics. Congratulations Aaron!
Population genetic inference based on the statistics of single loci, as summarized in the allele frequency spectrum, is known to be powerful for inferring demographic history. But substantial additional information is carried in two-locus statistics, which additionally capture patterns of linkage disequilibrium (LD). In this work, we developed a novel framework for demographic inference from… Read More »