Publications

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For citation information, see Google Scholar.

Submitted

  1. Behavioral caste is associated with distinct gene expression profiles in workers in Temnothorax rugatulus
    GM Leighton, X Wang, RN Gutenkunst, A Dornhaus
  2. How much research is spurred when a gene is associated with a complex disease?
    TJ Struck, BK Mannakee, RN Gutenkunst
    preprint
  3. Systematic effects of mRNA secondary structure on gene expression and molecular function in budding yeast
    X Wang, P Li, RN Gutenkunst
    preprint

In press

  1. Exome sequencing provides evidence of polygenic adaptation to a fat-rich animal diet in indigenous Siberian populations
    P Hsieh, B Hallmark, J Watkins, TM Karafet, LP Osipova, RN Gutenkunst, MF Hammer

2017

  1. Population genomics of Daphnia pulex
    M Lynch, R Gutenkunst, M Ackerman, K Spitze, Z Ye, T Maruki, Z Jia
    Genetics 206:315 (2017); link; pdf
  2. Genomic inferences of domestication events are corroborated by written records in Brassica rapa
    XC Qi, H An, AP Ragsdale, TE Hall, RN Gutenkunst, JC Pires, MS Barker
    Molecular Ecology 26:3373 (2017); link; pdf
  3. Inferring demographic history using two-locus statistics
    AP Ragsdale, RN Gutenkunst
    Genetics 206:1037 (2017); linkpdf

2016

  1. Computationally efficient composite likelihood statistics for demographic inference
    AJ Coffman, P Hsieh, S Gravel, RN Gutenkunst
    Molecular Biology and Evolution 33:591 (2016); link; pdf; supporting info
  2. Assessing models of speciation under different biogeographic scenarios; an empirical study using multi-locus and RNA-seq analyses
    T Edwards, M Tollis, P Hsieh, RN Gutenkunst, Z Liu, K Kusumi, M Culver, RW Murphy
    Ecology and Evolution 6:379 (2016); link; pdf
  3. Whole-genome sequence analyses of Western Central African Pygmy hunter-gatherers reveal a complex demographic history and identify candidate genes under positive natural selection
    P Hsieh, KR Veeramah, J Lachance, SA Tishkoff, JD Wall, MF Hammer, RN Gutenkunst
    Genome Research 26:279 (2016); link; pdf; supporting info
    Featured in the Arizona Daily Star; pdf
  4. Model-based analyses of whole genome data reveal a complex evolutionary history involving archaic introgression in Central African Pygmies
    P Hsieh, AE Woerner, JD Wall, J Lachance, SA Tishkoff, RN Gutenkunst, MF Hammer
    Genome Research 26:291 (2016); link; pdf; supporting info
  5. Selection on network dynamics drives differential rates of protein domain evolution
    BK Mannakee, RN Gutenkunst
    PLoS Genetics 12:e1006132 (2016); link; pdf; supporting text; supporting data
  6. Sloppiness and the geometry of parameter space
    BK Mannakee, AP Ragsdale, MK Transtrum, RN Gutenkunst
    in D Gomez-Cabrero and L Geris, editors, Uncertainty in Biology: a Computational Modeling Approach, Springer International (2016); link; pdf
  7. Triallelic population genomics for inferring correlated fitness effects of same site nonsynonymous mutations
    AP Ragsdale, AJ Coffman, P Hsieh, TJ Struck, RN Gutenkunst
    Genetics 203:513 (2016); link; pdf
    Highlighted by the editors of Genetics; pdf

2015

  1. Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast
    RA Hermansen*, BK Mannakee*, W Knecht, DA Liberles, RN Gutenkunst
    BMC Evolutionary Biology 15:232 (2015); link; pdf; supporting info; BioModel
  2. Testing whether metazoan tyrosine loss was driven by selection against promiscuous phosphorylation
    S Pandya, TJ Struck, BK Mannakee, M Paniscus, RN Gutenkunst
    Molecular Biology and Evolution 32:144 (2015); link; pdf

2014

  1. Loss of N-terminal acetylation suppresses a prion phenotype by modulating global protein folding
    WM Holmes, BK Mannakee, RN Gutenkunst, TR Serio
    Nature Communications 5:4383 (2014); link; pdf
  2. Effect of dedifferentiation on time to mutation acquisition in stem cell-driven cancers
    A Jilkine, RN Gutenkunst
    PLoS Computational Biology 10:e1003481 (2014); link; pdf; supporting info
  3. Sampling strategies for frequency spectrum-based population genomic inference
    JD Robinson, AJ Coffman, MJ Hickerson, RN Gutenkunst
    BMC Evolutionary Biology 14:254 (2014); link; pdf
  4. Evidence for increased levels of positive and negative selection on the X chromosome versus autosomes in humans
    K Veeramah, RN Gutenkunst, A Woerner, J Watkins, M Hammer
    Molecular Biology and Evolution 31:2267 (2014); link; pdf

2013

  1. Mathematical tools for evolutionary systems biology
    Loewe L, Swain P, Gutenkunst R
    Banff International Research Station meeting report; link; pdf
  2. Population genomic analysis of ten genomes reveals a rich speciation and demographic history of orang-utans (Pongo pygmaeus and Pongo abelii)
    X Ma, JL Kelley, K Eilertson, S Musharoff, JD Degenhardt, AL Martins, T Vinar, C Kosiol, A Siepel, RN Gutenkunst, CD Bustamante
    PLoS ONE 8:e77175 (2013); link; pdf
  3. Kinetics of coinfection with influenza A virus and Streptococcus pneumoniae
    AM Smith, FR Adler, RM Ribeiro, RN Gutenkunst, JL McAuley, JA McCullers, AS Perelson
    PLoS Pathogens 9:e1003238 (2013); link; pdf

2012

  1. Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically important genes
    X Xu*, X Liu*, S Ge*, JD Jensen*, F Hu*, X Li*, Y Dong*, RN Gutenkunst, L Fang, L Huang, J Li, W He, G Zhang, X Zheng, F Zhang, Y Li, C Yu, K Kristiansen, X Zhang, J Wang, M Wright, S McCouch, R Nielsen, J Wang, W Wang
    Nature Biotechnology 30:105 (2012); link; pdf

2011

  1. Guidelines for visualizing and annotating rule-based models
    LA Chylek, H Bin, ML Blinov, T Emonet, JR Faeder, B Goldstein, RN Gutenkunst, JM Haugh, T Lipniacki, RG Posner, J Yang, WS Hlavacek
    Molecular BioSystems 7:2779 (2011); link; pdf
  2. Demographic history and rare allele sharing among human populations
    S Gravel, BM Henn, RN Gutenkunst, AR Indap, GT Marth, AG Clark, The 1000 Genomes consortium, CD Bustamante
    Proceedings of the National Academy of Sciences USA 108:11983 (2011); link; pdf;abstract
    Featured in the New York Times; pdf
  3. A biophysical model of cell adhesion mediated by immunoadhesin drugs and antibodies
    RN Gutenkunst, D Coombs, T Starr, ML Dustin, B Goldstein
    PLoS ONE 6:e19701 (2011); link; pdf
  4. Comparative and demographic analysis of orang-utan genomes
    DP Locke, LW Hillier, WC Warren, KC Worley, LV Nazareth, DM Muzny, SP Yang, Z Wang, AT Chinwalla, P Minx, M Mitreva, L Cook, KD Delehaunty, C Fronick, H Schmidt, LA Fulton, RS Fulton, JO Nelson, V Magrini, C Pohl, TA Graves, C Markovic, A Cree, HH Dinh, J Hume, CL Kovar, GR Fowler, G Lunter, S Meader, A Heger, CP Ponting, T Marques-Bonet, C Alkan, L Chen, Z Cheng, JM Kidd, EE Eichler, S White, S Searle, AJ Vilella, Y Chen, P Flicek, J Ma, B Raney, B Suh, R Burhans, J Herrero, D Haussler, R Faria, O Fernando, F Darré, D Farré, E Gazave, M Oliva, A Navarro, R Roberto, O Capozzi, N Archidiacono, G Della Valle, S Purgato, M Rocchi, MK Konkel, JA Walker, B Ullmer, MA Batzer, AFA Smit, R Hubley, C Casola,DR Schrider, MW Hahn, V Quesada, XS Puente, GR Ordoñez, C López-Otín, T Vinar, B Brejova, A Ratan, RS Harris, W Miller, C Kosiol, HA Lawson, V Taliwal, AL Martins, A Siepel, A Roychoudhury, X Ma, J Degenhardt, CD Bustamante, RN Gutenkunst, T Mailund, JY Dutheil, A Hobolth, MH Schierup, OA Ryder, Y Yoshinaga, PJ de Jong, GM Weinstock, J Rogers, ER Mardis, RA Gibbs, RK Wilson
    Nature 469:529 (2011); link; pdf
    Featured in UANews; pdf
  5. Daily sampling of an HIV-1 patient with slowly progressing disease displays persistence of multiple env subpopulations consistent with neutrality
    H Skar*, RN Gutenkunst*, KW Ramsay, A Alaeus, J Albert, T Leitner
    PLoS ONE 6:e21747 (2011); link; pdf
  6. Effect of 1918 PB1-F2 expression on influenza A virus infection kinetics
    AM Smith, FR Adler, JL McAuley, RN Gutenkunst, RM Ribeiro, JA McCullers, AS Perelson
    PLoS Computational Biology 7:e1001081 (2011); link; pdf
  7. Discussion of “Riemannian manifold Langevin and Hamiltonian Monte Carlo methods” by Girolami and Calderhead
    MK Transtrum, RN Gutenkunst, Y Chen, BB Machta, JP Sethna
    Journal of the Royal Statistical Society: Series B 73:199 (2011); link; pdf

2010

  1. A map of human genome variation from population scale sequencing
    The 1000 Genomes Project Consortium
    Nature 467:1061 (2010); link; pdf
  2. RuleMonkey: Software for stochastic simulation of rule-based models
    J Colvin, MI Monine, RN Gutenkunst, WS Hlavacek, DD Von Hoff, RG Posner
    BMC Bioinformatics 11:404 (2010); link; pdf
  3. Genetics and genomics of human population structure
    S Ramachandran, H Tang, RN Gutenkunst, CD Bustamante
    in M Speicher et al., editors, Vogel and Motulsky’s Human Genetics: Problems and Approaches, Springer Verlag (2010); link; pdf

2009

  1. Targets of balancing selection in the human genome
    AM Andrés, MJ Hubisz, A Indap, D Torgerson, J Degenhardt, AR Boyko, RN Gutenkunst, TJ White, ED Green, CD Bustamante, AG Clark, R Nielsen
    Molecular Biology and Evolution 26:2755 (2009); link; pdf
  2. Global distribution of genomic diversity underscores rich complex history of continental human populations
    A Auton, K Bryc, AR Boyko, KE Lohmueller, J Novembre, A Reynolds, A Indap, MH Wright, J Degenhardt, RN Gutenkunst, KS King, MR Nelson, CD Bustamante
    Genome Research 19:795-803 (2009); link; pdf
  3. Inferring the joint demographic history of multiple populations from multidimensional SNP data
    RN Gutenkunst, RD Hernandez, SH Williamson, CD Bustamante
    PLoS Genetics 5:e1000695 (2009); link; pdf; supporting info
  4. Darwinian and demographic forces affecting human protein coding genes
    R Nielsen, MJ Hubisz, I Hellmann, D Torgerson, AM Andrés, A Albrechtsen, R Gutenkunst, MD Adams, M Cargill, X Hu, A Boyko, A Indap, CD Bustamante, AG Clark
    Genome Research 19:838 (2009); link; pdf

2008

  1. Variational method for estimating the rate of convergence of Markov Chain Monte Carlo algorithms
    FP Casey, JJ Waterfall, RN Gutenkunst, CR Myers, JP Sethna
    Physical Review E 78:046704 (2008); link; pdf
  2. Sloppiness, robustness, and evolvability in systems biology
    BC Daniels, YJ Chen, JP Sethna, RN Gutenkunst, CR Myers
    Current Opinion in Biotechnology 19:389 (2008); link; pdf
  3. Sloppiness, Modeling, and Evolution in Biochemical Networks
    RN Gutenkunst
    Ph.D. thesis, Cornell University (2008); link; pdf

2007

  1. Optimal experimental design in an epidermal growth factor receptor signalling and down-regulation model
    FP Casey, D Baird, Q Feng, RN Gutenkunst, JJ Waterfall, CR Myers, KS Brown, RA Cerione, JP Sethna
    IET Systems Biology 1:190 (2007); link; pdf
  2. Extracting falsifiable predictions from sloppy models
    RN Gutenkunst, FP Casey, JJ Waterfall, CR Myers, JP Sethna
    in G. Stolovitsky, A. Califano, J. Collins, editors, Reverse Engineering Biological Networks: Opportunities and Challenges in Computational Methods for Pathway Inference
    Annals of the New York Academy of Sciences 1115:203 (2007); link; pdf
  3. Inferring resource distributions from Atlantic bluefin tuna movements: an analysis based on net displacement and length of track
    R Gutenkunst, N Newlands, M Lutcavage, L Edelstein-Keshet
    Journal of Theoretical Biology 245:243 (2007); link; pdf
  4. Universally sloppy parameter sensitivities in systems biology
    RN Gutenkunst, JJ Waterfall, FP Casey, KS Brown, CR Myers, JP Sethna
    PLoS Computational Biology 3:e189 (2007); link; pdf; supporting info
    Featured in Biomedical Computation Review; pdf
    • “Exceptional” evaluation on Faculty of 1000: Biology
  5. Adaptive mutation in a geometrical model of chemotype evolution
    RN Gutenkunst, JP Sethna
    arXiv:0712.3240 (2007); link; pdf
  6. Python unleashed on systems biology
    CR Myers, RN Gutenkunst, JP Sethna
    Computing in Science and Engineering 9:34 (2007); link; pdf

2006

  1. Sloppy-model universality class and the Vandermonde matrix
    JJ Waterfall, FP Casey, RN Gutenkunst, KS Brown, CR Myers, PW Brouwer, V Elser, JP Sethna
    Physical Review Letters 97:150601 (2006); link; pdf

2003

  1. An introduction to signal extraction in interferometric gravitational wave detectors
    ED Black, RN Gutenkunst
    American Journal of Physics 71:365 (2003); link; pdf

2002

  1. Extracting light from water: sonoluminescence
    R Gutenkunst
    Caltech Undergraduate Research Journal 2:16 (2002); pdf